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The very first identified lysergamides came from the fungus termed ergot that are available on rye and various grains. This fungus contains both lysergic acid and a precursor of LSD, ergotamine. Ingestion of grains that contains ergot led to your affliction named “ergotism”, which wreaked havoc round the switch of the very first millennium. The worst incidence of the was just one evening within the calendar year 944AD in France, wherever Considerably in the inhabitants had been unknowingly consuming rye bread that experienced develop into infected with ergot.

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